Historic port scene at sunrise with peppercorn mound in the foreground

A Beginner's Guide to Piperine as a Natural Nootropic

The pursuit of wealth has compelled humans to embark on hazardous voyages throughout history, from exploring the New World's stormy coasts to navigating the exotic fragrances of the Malabar Coast.

The Californian Gold Rush of 1848, often hailed as a pivotal American Dream narrative, is just one chapter in our unending quest for prosperity and status.

However, well before gold seekers eyed the American West, the Indian subcontinent beckoned adventurers in 1498, during the Age of Discovery. European explorers ventured around the Cape of Good Hope and across the Indian Ocean, lured by the spice-rich Malabar Coast, thereby kindling the spice trade—a venture that would globally transform commerce and cultures.

A notable discovery in this era was black pepper, dubbed the "Black Gold" of the Middle Ages, so prized in Medieval Europe that it was even used as currency for rents and taxes, becoming a symbol of opulence and luxury.

Within the humble peppercorn is Piperine, a compound that has moved beyond its culinary origins to intrigue modern scientific research, particularly in cognitive enhancement and nutritional science.

Extracted from black pepper, Piperine is acclaimed not just for its culinary contributions but also for its health-promoting properties. Studies into Piperine have shown its ability to increase nutrient absorption, support cognitive health, and enhance overall wellness.



  • What is Piperine?
  • Piperine as a Nootropic
  • Scientific Evidence on Piperine's Benefits
  • Health Benefits Beyond Cognition
  • How to Use Piperine
  • Safety and Side Effects


A Beginner's Guide to Piperine as a Natural Nootropic


Lush peppercorn clusters hanging from vibrant leaves in soft-focus sunlight


What is Piperine?

Piperine is a fascinating compound that you might not have heard of by name, but you've likely experienced its effects if you've ever enjoyed the spicy kick of black pepper.

This natural substance is what gives black pepper its pungent flavor and is responsible for more than just spicing up our meals.

Definition and Background

Piperine is an alkaloid that occurs naturally in the fruits of the black pepper plant (Piper nigrum) and, to a lesser extent, in white pepper (Piper nigrum). It's recognized not only for its role in culinary applications but also for its potential health benefits and medicinal properties.

The interest in piperine extends beyond the kitchen and into the laboratory, where scientists are investigating its effects on health, metabolism, and cognitive function.

Chemical Composition of Piperine

On a molecular level, piperine is a compound belonging to the group of alkaloids, characterized by its nitrogen-containing structure. Its chemical formula is C17H19NO3, and it appears as a yellowish, crystalline substance at room temperature.

The compound is soluble in alcohol and slightly soluble in water, which contributes to its ability to interact with various substances within the body. This solubility plays a crucial role in piperine's biological effects, particularly in enhancing the bioavailability of other compounds and medications.

Historical Context and Traditional Uses

The use of black pepper and piperine dates back thousands of years, with its origins in ancient India.

It was highly prized in the spice trade, with its value sometimes equating to gold.

Traditional Indian medicine, known as Ayurveda, has utilized black pepper and piperine for a wide range of treatments, including relief from digestive issues, throat infections, and common colds.

Beyond its medicinal properties, piperine was used historically as a form of currency and a symbol of sacred offerings. Its journey from the Malabar Coast of India to the tables and medicine cabinets around the world is a testament to its enduring appeal and utility.

In traditional Chinese medicine, piperine has also been employed to treat various ailments, showcasing its importance across different cultures. From enhancing digestive health to serving as an anti-inflammatory agent, the historical and traditional uses of piperine reflect a deep-rooted appreciation for its diverse benefits.



Piperine as a Nootropic

Understanding Nootropics

Nootropics, often called smart drugs or cognitive enhancers, are substances that can improve cognitive function, particularly executive functions, memory, creativity, or motivation, in healthy individuals. They range from well-known caffeine to complex dietary supplements.

Piperine, with its potential to boost brain function, falls squarely into this category.

Enhancing Neurotransmitter Activity

Piperine has been shown to influence the brain's neurotransmitter levels, particularly serotonin and dopamine, which play crucial roles in mood regulation, motivation, and executive functions.

Studies suggest that piperine may enhance the availability of these neurotransmitters by inhibiting enzymes that break them down, thereby supporting improved mood and cognitive performance​​​​.

Modulating Brain's Reward System

Dopamine is central to the brain's reward system, influencing how we perceive pleasure and pain.

Piperine's ability to modulate levels of dopamine and other neurotransmitters suggests its potential to impact the brain's reward system positively. This could mean better mood regulation and potentially beneficial effects on motivation and pleasure-seeking behavior, making everyday tasks feel more rewarding.

Boosting Cognitive Function through Antioxidative and Anti-inflammatory Actions

Beyond neurotransmitter activity, piperine exhibits antioxidant and anti-inflammatory properties, contributing to its nootropic potential.

Oxidative stress and inflammation are two underlying factors that can impair cognitive function and contribute to neurodegenerative diseases.

Piperine's ability to combat these issues not only supports general brain health but may also protect against cognitive decline. This protective action extends to enhancing neuron viability and restoring mitochondrial function, crucial for energy production and cellular health​​​​.


Rustic table with peppercorns, health foods, and a mill in a bright kitchen


Scientific Evidence on Piperine's Benefits

Here's what scientific evidence has to say about the benefits of piperine:

Enhancing Bioavailability of Nutrients and Drugs

Piperine is a bioavailability enhancer. This means it can increase the amount of other substances your body can absorb and use. For instance, it has been found to enhance the systemic availability of various drugs and nutrients such as propranolol, theophylline, and curcumin when taken together​​.

This property of piperine could have significant implications for improving the effectiveness of dietary supplements and medications.

Neuroprotective Effects and Potential in Neurodegenerative Disease Management

Piperine has shown promise in the management of neurodegenerative diseases like Parkinson's and Huntington's disease. Studies indicate that piperine can mitigate behavioral impairments and provide neuroprotection against toxins that induce symptoms similar to these diseases​​.

It achieves these effects through various mechanisms, including antioxidant activity, anti-inflammatory effects, and by potentially restoring the balance of neurotransmitters in the brain.

Improving Mental Health: Antidepressant and Anxiolytic Effects

Mental health is another area where piperine shows potential. Research has demonstrated that piperine can have antidepressant-like effects, reducing the duration of immobility in animal models used to study depression. It may achieve this by modulating levels of neurotransmitters like serotonin and dopamine, which are crucial for mood regulation​​. Additionally, piperine has shown anxiolytic activity, suggesting it may help in reducing anxiety​​.



Health Benefits Beyond Cognition

Beyond its cognitive benefits, piperine offers a range of health advantages. These benefits are grounded in its antioxidative, anti-inflammatory properties, and its potential in pain management and gastrointestinal health.

Antioxidative and Anti-inflammatory Effects

Piperine has been recognized for its antioxidative and anti-inflammatory properties. Research indicates that it can protect against damage induced by various stressors in different body tissues.

For example, studies have shown piperine's protective effects against liver damage and its ability to enhance the antioxidant defense system in rats exposed to certain toxic substances​​. These effects are critical for maintaining cellular health and preventing chronic diseases linked to inflammation and oxidative stress.

Potential in Pain Management and Seizure Suppression

Piperine has shown promise in managing pain and suppressing seizures. In studies, it significantly reduced neuropathic pain in conditions like lumbar sciatica or carpal tunnel syndrome, highlighting its potential as a natural pain reliever​​.

Additionally, piperine has been reported to exert anti-seizure effects through various mechanisms, including modulation of the TRPV1 receptor, suggesting its potential use in epilepsy management​​.

Gastrointestinal Health and Digestive Enhancement

Piperine also plays a role in improving gastrointestinal health and enhancing digestion. It has been found to stimulate digestive enzymes in the pancreas and small intestine, contributing to the efficient breakdown and absorption of nutrients​​.

Moreover, piperine's impact on the digestive system includes promoting bile acid secretion, which is crucial for fat digestion and nutrient absorption. This action underscores piperine's role in supporting digestive health and possibly preventing digestive disorders​​.


How to Use Piperine

Here’s how you can incorporate piperine into your diet and wellness routine for its various health benefits:

Different Forms of Piperine Consumption

Piperine can be consumed in several forms, depending on your preference and the reason for its use. The most straightforward way to get piperine is by using black pepper in your cooking.

However, for more targeted health benefits, piperine is also available in supplement form, usually as capsules. These supplements often contain a concentrated dose of piperine, making it easier to consume in amounts that may have therapeutic effects​​.

Recommended Dosages for Health Benefits

While piperine is generally considered safe for consumption, the dosage can vary depending on the intended health benefit. For enhancing the absorption of other nutrients and drugs, dosages in clinical trials have ranged from 5 mg to 25 mg per day.

It's important to note that these dosages are typically used in combination with other substances to boost their bioavailability.

Timing and Combining with Other Supplements

Piperine can be taken at any time of day, but for maximizing its bioenhancement properties, it’s often recommended to take it alongside the nutrient or medication it’s meant to amplify. For instance, pairing piperine with curcumin (the active compound in turmeric) significantly increases curcumin's bioavailability.

This synergistic effect is seen with various other compounds as well, including beta-carotene and coenzyme Q10, among others. The key to successful use is timing the intake of piperine to coincide with that of the other supplement or medication​​.


Extreme close-up of a single peppercorn with dramatic lighting and dark background


Safety and Side Effects

General Safety of Piperine

Piperine has been consumed for centuries as part of black pepper, without significant safety concerns when used in culinary amounts.

Research supports its safety, highlighting its long history of use in food and traditional medicine. For instance, studies have shown that piperine does not produce toxic effects when consumed daily in foods, even though it can act as an irritant if consumed in higher quantities​​.

Potential Side Effects and Precautions

While generally safe, piperine can have adverse effects at high doses. For instance, acute toxicity has been observed in animals with high doses of piperine, indicating potential toxic effects on the liver and other organs at these higher concentrations​​. It's crucial to adhere to recommended dosages and be mindful of piperine's potent bioenhancing properties, which can increase the absorption and effect of various compounds and medications.

Interactions with Medications and Specific Health Conditions

Piperine can influence the metabolism of drugs, including those processed by cytochrome P450 enzymes, affecting their bioavailability. This interaction can be beneficial, as seen with certain nutrients and drugs, but it also poses a risk of altering the pharmacokinetics of medications, leading to potential overmedication or adverse effects​​.

Importance of Moderation and Consulting with a Healthcare Professional

Given its powerful effects and potential interactions with medications, moderation is key when incorporating piperine into your health routine. Consulting with a healthcare professional is essential, especially for individuals with existing health conditions or those taking prescription medications. This ensures the safe and effective use of piperine as part of a health regimen or treatment plan​​.



Piperine offers a variety of health benefits that extend beyond its nootropic properties. Its ability to enhance the bioavailability of nutrients and drugs, provide neuroprotective effects, manage pain, support gastrointestinal health, and improve mental health, makes it a compound of interest for those looking to improve their overall wellness and cognitive function.

Furthermore, its antioxidative and anti-inflammatory actions contribute to its wide range of therapeutic applications.

Considering the broad spectrum of benefits piperine can offer, incorporating it into your wellness and cognitive enhancement regimens could be beneficial.

Whether using black pepper in cooking or taking piperine supplements, it's a simple addition that could have a significant impact on your health. However, as with any supplement, it's crucial to use piperine responsibly and in consultation with a healthcare professional, especially if you're taking other medications or have existing health conditions.

Integrating piperine into your routine could be a step toward enhanced cognitive function and overall well-being.

Are you considering joining the ranks of those who have experienced the cognitive benefits of nootropics? To learn more about how our Mood & Wellbeing Nootropic Supplement might fit into your lifestyle, visit us at nooroots.


Frequently Asked Questions

What is piperine?

Piperine is an alkaloid found in black pepper, known for enhancing the bioavailability of various nutrients and compounds, including nootropics.

How does piperine work as a nootropic?

Piperine enhances cognitive function indirectly by increasing the absorption and effectiveness of other nootropic compounds.

Can piperine improve memory?

While piperine itself does not directly improve memory, it enhances the absorption of memory-boosting nootropics, thereby supporting cognitive function.

Is piperine safe for daily use?

Piperine is generally safe for daily use in moderate amounts, but high doses may cause gastrointestinal discomfort. Consulting a healthcare provider is advisable.

What are the benefits of piperine for the brain?

Piperine improves brain health by enhancing the bioavailability of beneficial compounds, supporting better cognitive function and neuroprotection.

How much piperine should I take for cognitive benefits?

Typical dosages range from 5 to 20 mg per day, often included in supplements to enhance absorption of other active ingredients.

Are there any side effects of taking piperine?

Some individuals may experience mild side effects such as digestive upset. High doses can lead to more severe gastrointestinal issues.

Can piperine help with anxiety and depression?

Piperine may help by enhancing the absorption of compounds known to reduce anxiety and depression, like curcumin and certain vitamins.

What is the best way to take piperine for nootropic effects?

Piperine is best taken in combination with other nootropics or nutrients to enhance their absorption. It is commonly found in capsule form.

How long does it take to see the effects of piperine on cognitive function?

The effects of piperine on cognitive function depend on the enhanced absorption of other nootropics, which can vary from a few days to several weeks.


Learn more about the vitamins, minerals and plant extracts we use to give your brain a daily boost



  • Ademuyiwa, O. H., Fasogbon, B. M., & Adebo, O. A. (2021). The potential role of Piper guineense (black pepper) in managing geriatric brain aging: a review. Critical Reviews in Food Science and Nutrition, 63(16), 2840–2850. https://doi.org/10.1080/10408398.2021.1980764
  • Azam, S., Park, J., Kim, I., & Choi, D. (2022). Piperine and its metabolite’s pharmacology in neurodegenerative and neurological diseases. Biomedicines, 10(1), 154. https://doi.org/10.3390/biomedicines10010154
  • Balakrishnan, R., Azam, S., Kim, I., & Choi, D. (2023). Neuroprotective effects of black pepper and its bioactive compounds in Age-Related Neurological Disorders. Aging and Disease, 14(3), 750. https://doi.org/10.14336/ad.2022.1022
  • Che, W., Cai, Z., Wang, W., Wei, M., Kou, D., Li, T., Yang, Z., Guo, H., Le, W., & Li, S. (2019). Piperine attenuates cognitive impairment in an experimental mouse model of sporadic Alzheimer’s disease. ˜the œJournal of Nutritional Biochemistry, 70, 147–155. https://doi.org/10.1016/j.jnutbio.2019.05.009
  • Mao, Q., Huang, Z., Zhang, X., Xian, Y., & Ip, S. (2014). Brain-derived neurotrophic factor signalling mediates the antidepressant-like effect of piperine in chronically stressed mice. Behavioural Brain Research, 261, 140–145. https://doi.org/10.1016/j.bbr.2013.12.020
  • Mao, Q., Xian, Y., Ip, S., & Che, C. (2011). Involvement of serotonergic system in the antidepressant-like effect of piperine. Progress in Neuro-psychopharmacology & Biological Psychiatry, 35(4), 1144–1147. https://doi.org/10.1016/j.pnpbp.2011.03.017
  • Mori, A., Kabuto, H., & Pei, Y. (1985). Effects of piperine on convulsions and on brain serotonin and catecholamine levels in E1 mice. Neurochemical Research, 10(9), 1269–1275. https://doi.org/10.1007/bf00964845
  • Ren, T., Wang, Q., Li, C., Yang, M., & Zuo, Z. (2017). Efficient brain uptake of piperine and its pharmacokinetics characterization after oral administration. Xenobiotica, 48(12), 1249–1257. https://doi.org/10.1080/00498254.2017.1405293
  • Salman, M., Tabassum, H., & Parvez, S. (2020). Piperine mitigates behavioral impairments and provides neuroprotection against 3-nitropropinoic acid-induced Huntington disease-like symptoms. Nutritional Neuroscience, 25(1), 100–109. https://doi.org/10.1080/1028415x.2020.1721645
  • Song, L., Che, W., Li, W., Koike, K., Nikaido, T., & Wang, M. W. (2007). Antidepressant-like effects of piperine and its derivative, antiepilepsirine. Journal of Asian Natural Products Research, 9(5), 421–430. https://doi.org/10.1080/10286020500384302
  • Srinivasan, K. (2007). Black Pepper and its Pungent Principle-Piperine: A Review of Diverse Physiological Effects. Critical Reviews in Food Science and Nutrition, 47(8), 735–748. https://doi.org/10.1080/10408390601062054
  • Stojanović-Radić, Z., Pejčić, M., Dimitrijević, M., Aleksić, A., N, A. K., Salehi, B., Cho, W. C., & Sharifi‐Rad, J. (2019). Piperine-A major Principle of Black Pepper: A review of its bioactivity and studies. Applied Sciences, 9(20), 4270. https://doi.org/10.3390/app9204270
  • Wattanathorn, J., Chonpathompikunlert, P., Muchimapura, S., Priprem, A., & Tankamnerdthai, O. (2008). Piperine, the potential functional food for mood and cognitive disorders. Food and Chemical Toxicology, 46(9), 3106–3110. https://doi.org/10.1016/j.fct.2008.06.014
  • Yun, Y. S., Noda, S., Takahashi, S., Takahashi, Y., & Inoue, H. (2017). Piperine-like alkamides from Piper nigrum induce BDNF promoter and promote neurite outgrowth in Neuro-2a cells. Natural Medicines/Journal of Natural Medicines, 72(1), 238–245. https://doi.org/10.1007/s11418-017-1140-3
Back to blog

Explore nooroots

1 of 2