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Do Nootropic Supplement Stacks Actually Work?

In an era increasingly dominated by a quest for peak mental performance, the allure of nootropic stacks has never been stronger. Coined by Dr. Corneliu E. Giurgea in 1972, the term "nootropic" derives from the Greek words "nous," meaning mind, and "trepein," to bend.

This etymology beautifully captures the essence of nootropics: substances designed to "bend the mind" towards enhanced cognitive function.

Originally, the concept was rooted in the desire for substances that could offer cognitive benefits without the side effects commonly associated with psychoactive drugs.

Over time, the practice of using individual nootropics expanded into the realm of nootropic stacks, where the synergistic potential of combining various cognitive enhancers promises a new frontier in mental optimization.

Nootropics, often dubbed "smart drugs" or cognitive enhancers, are agents that can improve aspects of cognitive function, such as executive functions, memory, creativity, or motivation, in healthy individuals.

The practice of stacking these substances—combining different nootropics into a unified regimen—aims to amplify their individual benefits, creating a tailored approach to cognitive enhancement that has captivated the interest of many.

This blog ventures deep into the layered world of nootropic stacks, examining their benefits, the scientific evidence that supports their use, and the lingering questions yet to be answered.

By weaving together insights from seminal and recent studies, we endeavor to illuminate whether these sophisticated blends of cognitive enhancers are the key to unlocking unparalleled mental prowess or if they merely cast the illusion of improvement.

Learn more about our Mood & Wellbeing Nootropic Supplement at nooroots. If you have any questions after exploring this post, our support resources and online contact form are readily accessible with just a click.



  • What is a Nootropic stack?
  • What are the Benefits of Combining Nootropics?
  • Scientific Evidence of Multi-Ingredient Nootropic Stacks
    • Chronic supplementation of a multi-ingredient herbal supplement
    • Acute Effect of a Dietary Multi-Ingredient Nootropic as a Cognitive Enhancer in Young Healthy Adults
    • The effects of a multi-ingredient cognitive formula on alertness, focus, motivation, calmness and psychomotor performance in comparison to caffeine and placebo
    • Efficacy of the nootropic supplement on memory in adults
  • What the Science Says (and doesn't say)
  • Data versus Anecdotal Evidence


    Do Nootropic Supplement Stacks Actually Work?


    A glowing capsule on a wooden surface represents advanced nootropics


    What is a Nootropic Stack?

    Nootropic stacking stands at the forefront of cognitive enhancement, embodying the strategic amalgamation of various supplements to elevate brain function beyond what single supplements can achieve.

    This innovative approach goes beyond mere additive effects, tapping into the synergy between different components to unlock new levels of mental performance.

    The essence of nootropic stacking lies in its holistic strategy; it aims to cater to a broad spectrum of cognitive needs simultaneously.

    Whether the goal is to bolster memory, sharpen focus, enhance creativity, or maintain mental clarity, a well-designed stack addresses these needs in a coordinated manner.

    The beauty of this approach is in its customization: stacks can be tailored to meet individual cognitive goals, preferences, and responses, allowing for a personalized pathway to enhanced brain function.

    Nootropic stacking doesn't dwell on specific ingredients; rather, it emphasizes the concept of synergy. By carefully combining supplements that complement each other's effects, users can achieve a balanced enhancement of mental faculties.

    This can mean pairing elements that work on different aspects of brain health or those that mutually enhance each other's potency, resulting in a comprehensive cognitive boost.

    The process of building an effective nootropic stack is akin to crafting a bespoke mental wellness regimen.

    It involves understanding the broad categories of cognitive enhancement—such as memory support, focus amplification, mood stabilization, and creativity enhancement—and how different supplements can contribute to these areas.

    Starting with a foundational understanding of these categories allows for the thoughtful selection and combination of supplements, ensuring that the stack is not only effective but also harmonious, with minimal risk of adverse interactions.

    Adopting a nootropic stack requires a mindful approach. Beginners are encouraged to start with simpler combinations, gradually adjusting based on personal experiences and outcomes.

    This iterative process is crucial, as it respects the body's unique responses and allows for fine-tuning the stack for optimal results.

    Moreover, engaging with the wider community or seeking professional advice can provide valuable insights and guidance on constructing a stack that aligns with one's cognitive aspirations and health considerations.


    What are the Benefits of Combining Nootropics?

    Combining nootropics into a stack represents a holistic approach to enhancing cognitive function and overall brain health.

    This method leverages the synergy between various nootropics to achieve a broader and more profound impact on cognitive processes, including memory, focus, creativity, and mood regulation.

    Here we explore how combining mechanisms can lead to enhanced outcomes.

    Note that this list is not exhaustive and is intended more as an illustration of the thought process behind the desire to stack, or combine, nootropics based on individual goals:

    • Enhanced Cognitive Enhancement: Combining nootropics that enhance different cognitive functions—such as one that improves neural communication for better memory recall with another that increases cerebral blood flow for enhanced concentration—can lead to a more holistic enhancement of cognitive performance. Explore the difference between nootropics and stimulants for focus and concentration
    • Balanced Neurochemical Support: One nootropic might increase the availability of neurotransmitters like acetylcholine, essential for learning and memory, while another could enhance receptor sensitivity, ensuring that the brain can effectively use these neurotransmitters. This combination ensures a balanced approach to neurochemical support, maximizing cognitive function. Discover nootropics for learning & memory.
    • Stress Reduction and Mood Improvement: Stress reduction can be achieved by combining a nootropic that lowers cortisol levels, the body's primary stress hormone, with another that boosts feel-good neurotransmitters such as serotonin or dopamine. This dual approach not only mitigates the effects of stress on the body but also promotes a positive mood state, contributing to better mental health and resilience. Learn more about the best nootropics for stress.
    • Enhanced Neuroprotection: By combining nootropics, one of which may offer antioxidant properties to combat oxidative stress and another that stimulates the growth of new neurons (neurogenesis), a comprehensive neuroprotective strategy can be formed. This not only guards against cognitive decline but also supports the brain's ability to repair and renew itself.
    • Synergistic Effects for Greater Efficacy: The principle of synergy implies that the combined effect of multiple nootropics can be greater than the sum of their individual effects. This can lead to more significant cognitive enhancements than would be possible when taking single nootropics in isolation.
    • Customization for Personal Needs: Through combining nootropics, individuals have the flexibility to address specific cognitive concerns or goals. For instance, someone looking to improve both memory and attention might combine a nootropic that enhances long-term potentiation (a mechanism for memory storage) with another that reduces distractions by modulating the release of norepinephrine.
    • Optimized Dosages and Minimized Side Effects: By leveraging the synergistic effects of combined nootropics, it's often possible to use lower doses of each, achieving the desired cognitive benefits while reducing the potential for side effects. This approach ensures a safer and more sustainable path to cognitive enhancement.


    A multitude of capsules and plants atop a tech-inspired platform


    Scientific Evidence of Multi-Ingredient Nootropic Stacks

    Chronic supplementation of a multi-ingredient herbal supplement

    In the recent study published in Frontiers in Nutrition, Wightman, E. L., Khan, J., Smith, E. M. L., and colleagues explore the impact of chronic supplementation with a multi-ingredient herbal supplement on cognitive performance in older adults.

    Titled "Chronic supplementation of a multi-ingredient herbal supplement increases speed of cognitive task performance alongside changes in the urinary metabolism of dopamine and the gut microbiome in cognitively intact older adults experiencing subjective memory decline," this research offers new insights into how natural supplements might support cognitive functions.

    Here, we will examine some of the key findings from this study, aiming to present a clear overview of its contributions to our understanding of cognitive health and the potential roles of nootropic supplements.


    The study focused on exploring the impact of a multi-ingredient herbal supplement on cognitive function in older adults who experience subjective memory decline.

    Specifically, it aimed to:

    1. Assess the effects of chronic (12-week) supplementation of a multi-ingredient herbal supplement on cognitive function. This supplement contained a blend of Bacopa monnieri, Gotu kola leaf, Turmeric whole powder, Reishi full spectrum, Rosemary, Cardamom, Holy Basil, Turmeric Wholistic™ extract, Green Tea, and Seagreens. The target population was older adults, aged between 55–75 years, who self-reported experiencing a decline in memory but were otherwise cognitively intact.
    2. Investigate whether the observed cognitive effects, if any, were underpinned by shifts in microbial composition and/or metabolism of the herbs. This secondary objective was focused on understanding the biological pathways through which the supplement might exert its effects, including changes in the gut microbiome and urinary metabolomics.


    The study's objectives were carefully designed to fill a gap in the existing literature on the effects of herbal supplements, which often focus on single-ingredient effects rather than the complex interactions and combined effects of multi-ingredient supplements.

    By including assessments of the gut microbiome and urinary metabolomics, the study also sought to provide insights into the mechanistic pathways that might mediate the cognitive effects of such supplements.


    Participants were required to complete lab-based cognitive assessments and provide stool and urine samples at baseline and following 90 days of either the multi-ingredient herbal or placebo supplementation.

    The herbal supplement, known as "Turmeric Brainwave," contained a proprietary blend of several herbs known for their potential cognitive benefits.

    The cognitive assessments included a comprehensive battery of tests designed to measure various aspects of cognitive performance, such as memory, attention, and speed of processing.

    Additionally, the study incorporated the analysis of gut microbiota and urinary metabolomics to explore potential shifts in microbial composition and metabolism that could underlie the cognitive effects observed.

    The gut microbiome analysis involved collecting stool samples from participants and analyzing them using sequencing technologies to identify changes in bacterial species.

    The urinary metabolomics analysis aimed to detect shifts in the metabolism of specific compounds related to the supplementation.

    The statistical analysis was planned to identify significant differences between the treatment and placebo groups across the cognitive assessments, gut microbiome composition, and urinary metabolic profiles.


    The results of the study on chronic supplementation of a multi-ingredient herbal supplement in cognitively intact older adults experiencing subjective memory decline show a notable influence on cognitive performance and biological markers.

    The findings indicate that the supplementation led to improvements focused on the speed of cognitive task performance.

    Specifically, there were observed enhancements in the speed of processing in tasks that demand rapid visual information processing, alongside an improvement in the false alarm rate on a task requiring rapid decision-making based on visual stimuli.

    In simpler terms, the graph shows how well people did on certain tests at different times, but it doesn't show all the detailed comparisons because there are too many and they might not all be that important.

    For the most part, these comparisons are about how the placebo group (people who didn't get the real supplement) did on the second test after taking their dose on the 90th day compared to how both groups did at other times.

    However, there's one specific point where the groups were directly compared: on the 90th day, after the second dose, people who took the placebo were a bit slower on a test that measures how quickly they react (taking about 589.63 milliseconds) compared to those who took the multi-ingredient herbal supplement (who were quicker at 551.12 milliseconds).

    This difference was significant, showing that the herbal supplement might have helped people react faster.

    Interestingly, these cognitive benefits coincided with changes in urinary metabolomics and gut microbiome profiles.

    An increased presence of tyrosine in the urinary metabolome was noted, which may suggest a role for dopamine—a neurotransmitter involved in various brain functions, including motivation, reward, and motor control—in these cognitive improvements.

    This aligns with the understanding that dopamine plays a crucial role in cognitive processes, particularly those related to attention and response speed.

    Moreover, the supplementation led to a significant reduction in levels of three bacterial species within the gut microbiome.

    One species, Sutterella, has been notably associated with lower levels of constipation reported by participants in the supplement group, suggesting a potential benefit to gastrointestinal health and function.

    This finding adds to the growing body of evidence supporting the gut-brain axis, where changes in the gut microbiome can influence neurological and cognitive functions.

    The study presents evidence that chronic supplementation with a multi-ingredient herbal supplement can improve the speed of cognitive task performance in older adults.

    These improvements are accompanied by changes in the urinary metabolism of dopamine and alterations in the gut microbiome, highlighting a complex interaction between dietary supplements, gut health, and brain function.

    However, it is also noted that the interpretation of the negative effects on memory and the potential implications of these findings are constrained by the unequal randomization of participants into treatment groups, which was further complicated by the COVID-19 pandemic.

    This suggests that while the study unveils promising avenues for enhancing cognitive health through dietary supplementation, further research is needed to fully understand the mechanisms at play and the potential for such interventions in broader populations.

    Acute effect of a dietary multi-ingredient nootropic as a cognitive enhancer in young healthy adults

    In a notable study detailed in Frontiers in Nutrition, Medrano, M., Molina-Hidalgo, C., Alcantara, J. M. A., Ruiz, J. R., & Jurado-Fasoli, L. set out to explore the immediate impact of a multi-ingredient nootropic on cognitive functions and emotional states in young, healthy adults.

    Titled "Acute effect of a dietary Multi-Ingredient Nootropic as a Cognitive Enhancer in Young Healthy Adults: A Randomized, Triple-Blinded, Placebo-Controlled, Crossover Trial," this research provides a closer look at how such supplements might offer cognitive benefits shortly after consumption.

    The study's approach and rigorous design offer valuable insights into the potential for nootropics to enhance various aspects of cognitive performance, including processing speed, memory, and flexibility, without adverse effects on heart rate or emotional well-being.


    The objectives of the study were cantered on exploring the acute effects of a multi-ingredient dietary nootropic on cognitive functions among young, healthy adults.

    This research was thoroughly designed to:

    1. Examine the immediate impact of a specific multi-ingredient nootropic blend on various cognitive performance indicators, including processing speed, inhibitory control, spatial working memory, cognitive flexibility, creativity, and verbal fluency. The primary focus was to understand how this supplement could potentially enhance cognitive abilities within a short period after consumption.
    2. Investigate the potential influences of the dietary multi-ingredient nootropic on emotional states, heart rate (HR), and heart rate variability (HRV). This secondary objective aimed to assess whether the cognitive enhancements, if any, come at the expense of altered emotional states or cardiovascular metrics, which could indicate stress or other negative physiological responses.


    The investigation was grounded in the growing interest and use of nootropics among healthy individuals, aimed at improving cognitive performance, psychosocial, and emotional states.

    It leveraged a rigorous randomized, triple-blinded, placebo-controlled, crossover trial methodology to ensure the reliability and validity of its findings.

    The selected population for this study comprised young healthy adults, acknowledging this demographic's increasing interest in cognitive enhancement strategies for academic and professional performance improvements.


    This study enrolled 26 young, healthy adults, evenly split by gender, with an average age of 24.9 years.

    These participants were subjected to a detailed screening process to ensure they met specific health criteria, thereby ensuring the reliability and safety of the trial.

    The study was uniquely designed to investigate the acute cognitive effects of a 10g dose of a dietary multi-ingredient nootropic, compared to a placebo, on various cognitive performance aspects such as processing speed, inhibitory control, working memory, cognitive flexibility, creativity, and verbal fluency.

    The nootropic and placebo were consumed in a randomized order, with a washout period between sessions to avoid carry-over effects.

    This careful approach ensured that the findings would accurately reflect the nootropic's effects on cognitive performance.

    To assess cognitive performance, a comprehensive battery of cognitive tests was employed, measuring various dimensions of cognitive function.

    These assessments provided a nuanced understanding of the nootropic's impact on cognitive abilities, enhancing the study's contribution to the field of cognitive enhancement research.

    The emotional state and physiological responses (heart rate and heart rate variability) were also measured, providing a holistic view of the nootropic's effects.


    The results indicated significant enhancements in cognitive functioning following the consumption of the nootropic compared to a placebo.

    Specifically, participants experienced improved response times across several cognitive tests, including those measuring processing speed, inhibitory control, spatial working memory, and cognitive flexibility.

    The effect sizes for these improvements ranged from moderate to large (0.4–0.6), underscoring the substantial impact of the nootropic on cognitive performance.

    Furthermore, the nootropic intake was associated with increased accuracy in tasks assessing processing speed, inhibitory control, and cognitive flexibility. Imagine our brain as a computer; the nootropic is like a software update that makes certain programs run faster and more accurately.

    The graph is divided into four main sections that correspond to different thinking skills:

    • Processing Speed (Figures A and B): This is about how quickly people can react to things they see, like hitting the brake pedal when a light turns red. After taking the nootropic, people were faster (which is good) at hitting a button when prompted during a test, compared to when they took a placebo (which is basically a sugar pill with no effects). Not only were they quicker, but they also made fewer mistakes.
    • Inhibitory Control (Figures C and D): This skill is about resisting distractions and staying focused. It's like ignoring your phone notifications while you're studying. Again, with the nootropic, people got better at this. They could ignore distractions and respond correctly to the tasks more often than with the placebo.
    • Working Memory (Figures E, G, I, F, H, J): Think of this as keeping a few things in your mind at the same time, like remembering a short grocery list without writing it down. The results here are a mixed bag. While people reacted faster on the tasks that tested this skill after taking the nootropic, their accuracy didn't change much compared to the placebo.
    • Cognitive Flexibility (Figures K, M, L, N): This is about switching between different tasks without getting mixed up. Like if you're cooking and answering texts at the same time. People were quicker to switch their attention between tasks and made more correct responses after taking the nootropic than when they took the placebo.

    All these effects are measured by comparing the performance on the nootropic with the performance on the placebo.

    The "P" values you see tell us whether the differences are likely due to the nootropic or just by chance. A "P" value less than 0.05 (like P=0.008) means it's very likely the improvements were because of the nootropic.

    In short, the nootropic helped people process information faster and more accurately, focus better, remember multiple items more quickly, and switch between tasks more effectively.

    However, it didn't seem to make a difference in how many things they could remember at once or how well they could find words, which is what the working memory and verbal fluency tests were all about.

    The study also revealed that participants displayed higher creativity and experienced more positive emotions post-consumption, with reduced feelings of sadness and depression.

    Interestingly, the nootropic did not significantly affect heart rate or heart rate variability, suggesting that its cognitive benefits do not come at the cost of cardiovascular stress.


    This graph is showing us how taking a nootropic influenced people's creativity compared to not taking anything (placebo).

    There are three parts to this graph:

    • Correct Total Items (Figure A): This is like a score of good ideas. After taking the nootropic, people came up with more good ideas than when they didn't take anything. The "P=0.014" tells us this improvement is likely because of the nootropic and not just by chance.
    • Incorrect Answers (Figure B): This shows the number of ideas that weren't quite right. Even the best creatives have ideas that don't work out, and here, there were slightly more of these after the nootropic. The "P=0.026" means there's a small chance that the nootropic led to more of these not-so-great ideas.
    • Total Score (Figure C): This combines the good and not-so-good ideas to give an overall creativity score. After taking the nootropic, people's total creativity scores were higher compared to the placebo, meaning the nootropic likely helped them think outside the box more effectively.

    After taking the nootropic people's brains seemed to be on a creative spree, with a noticeable increase in good ideas, a few more not-so-great ones, and an overall boost in creativity compared to when they took a placebo.

    The "P" values are a bit like a confidence level; the lower the number (under 0.05), the more confident we are that the nootropic was responsible for the change.

    This graph shows us how people's emotions changed after taking a brain-boosting supplement compared to a placebo (a fake supplement that doesn't do anything).

    Each dot represents a person's change in feeling or mood after taking the supplement.

    The significant results are:

    • Positive Emotions (Figure A): People felt more positive after taking the nootropic. This is shown by the lower "P" value (P=0.005), which tells us it's very likely that the nootropic made people feel more upbeat.
    • Sadness-Depression (Figure G): The nootropic seemed to help reduce feelings of sadness or depression (P=0.033), which is a pretty good indication that the supplement made people feel less blue.

    All the other feelings like negative emotions, motivation, feeling driven or regulated by external rewards, feeling unmotivated, feeling angry or hostile, feeling anxious, happy, or anxious as a personality trait, didn't change much whether people took the nootropic or the placebo — the "P" values were all above 0.05, which means we can't be sure the supplement had any effect on these feelings. 

    It looks like this special supplement might help people feel more positive and less sad after doing some brainy tests, but it doesn't seem to change how motivated or happy they are, nor does it have a big impact on their anxiety or anger levels.

    It is important to note that there were no significant differences between the nootropic and placebo in verbal fluency, motivation, or anxiety, indicating that the cognitive enhancements were specific to certain areas of cognitive function.

    These findings contribute to a growing body of research supporting the use of dietary supplements to enhance cognitive performance in healthy adults, potentially offering a safe and effective means to boost mental functioning in various contexts.


    A transparent capsule with sprouting elements over scattered pills


    The effects of a multi-ingredient cognitive formula on alertness, focus, motivation, calmness and psychomotor performance

    In a study published in the Journal of the International Society of Sports Nutrition, Shields, K. A., et al. (2014) undertook an investigation to discern the effects of a multi-ingredient cognitive formula on various cognitive and physical performance metrics in comparison to caffeine and a placebo.

    Titled "The effects of a multi-ingredient cognitive formula on alertness, focus, motivation, calmness and psychomotor performance compared to caffeine and placebo," this research aims to provide insight into the potential benefits of a stimulant-free pre-workout supplement on enhancing cognitive functions such as alertness, focus, calmness, and motivation, alongside assessing its impact on psychomotor performance metrics like reaction times and vertical jump power.

    This exploration into stimulant-free cognitive enhancement options offers a promising alternative for individuals sensitive to caffeine and those seeking to optimize both their mental and physical performance without the associated negative side effects of traditional stimulants.


    This research aimed to evaluate the effectiveness of a multi-ingredient cognitive formula compared to caffeine and a placebo in influencing various cognitive and physical parameters.

    The study's objectives were intricately designed to:

    1. Investigate the impact of a stimulant-free pre-workout formula on cognitive functions such as alertness, focus, calmness, and motivation. Unlike traditional supplements that rely heavily on caffeine, this study explores alternative ingredients that could offer similar benefits without the associated adverse effects.
    2. Assess the effects of the cognitive formula on psychomotor performance, specifically targeting reaction time, motor reaction time, memory, and vertical jump power. By incorporating these performance metrics, the study extends beyond cognitive function to understand how these elements might interact and affect overall physical performance.
    3. Compare the outcomes of the cognitive formula to those of caffeine and a placebo to determine its relative efficacy. Given the prevalent use of caffeine in pre-workout supplements and its known effects, establishing a comparison provides a clear benchmark for evaluating the multi-ingredient formula's potential advantages or drawbacks.
    4. Examine the potential for the cognitive formula to enhance cognitive functions without the unwanted side-effects associated with caffeine consumption. By focusing on alternatives to caffeine, the study aims to explore the possibility of improving pre-workout cognition and performance in a way that is accessible to individuals sensitive to stimulants.



    The study places a strong emphasis on exploring stimulant-free alternatives to enhance cognitive and psychomotor performance in athletic contexts, providing valuable insights for athletes, coaches, and individuals interested in optimizing their mental and physical preparation for performance.


    The methodology centered around a double-blind, placebo-controlled, randomized crossover design, ensuring the reliability and validity of the results.

    Five college-aged males were recruited to participate in this rigorous investigation.

    The participants were randomly assigned to consume one of three supplements: MindSet (manufactured by Haleo Inc., San Diego, CA), caffeine, or a placebo (constituted of rice flour). This setup was critical for maintaining the study's integrity and minimizing biases.

    The study's protocol required subjects to consume their assigned supplement 30 minutes prior to the testing phase.

    A 48-hour wash-out period was instituted between tests to prevent carryover effects, which could compromise the study's outcomes.

    Participants underwent a series of comprehensive mental aptitude tests, visual reaction tests, and power output measurements, designed to cover a broad spectrum of cognitive and physical domains.

    Measurements and Assessments

    The cognitive and physical performance of the participants was evaluated using a diverse array of tests:

    • Mental Aptitude: Alertness, focus, calmness, and motivation were measured on an interval scale, providing a quantitative assessment of cognitive states.
    • Cognition: A serial subtraction test was utilized to measure cognitive processing, with improvements in scores from pre- and post-testing being carefully noted.
    • Reaction Times: Both reaction time (RT) and motor reaction time (MRT) were assessed using the Dynavision system, a tool for measuring visual and motor response speeds.
    • Power Output: Vertical Jump Power was measured via the Vertical Jump Test, employing a Tendo Unit to quantify power output in a physical context.

    The approach to measurement and assessment allowed for a holistic evaluation of the supplements' effects on both cognitive and physical performance domains.


    The results demonstrated significant enhancements across a range of cognitive and physical metrics:

    • Alertness experienced a substantial increase of 56%.
    • Focus improved by an impressive 58%.
    • Motivation was boosted by 43%.
    • Cognition, measured through tasks such as serial subtraction, saw a 26% improvement, on par with the results observed for caffeine.
    • Memory performance saw an uplift of 15%.
    • Vertical Jump Power, a metric of psychomotor performance, was enhanced by 3%.
    • Interestingly, Calmness also saw a positive adjustment, increasing by 6%, in stark contrast to the decrease in calmness observed with caffeine consumption.

    Caffeine, while effective in increasing alertness, focus, cognition, memory, motivation, and vertical jump power by 19%, 35%, 26%, 11%, 10%, and 1% respectively, also led to an 18% decrease in calmness.

    These results underscore the potential of the nootropics blend as a stimulant-free alternative to caffeine for the enhancement of cognitive functions and physical performance, without the adverse effects typically associated with caffeine, such as decreased calmness.

    Efficacy of the nootropic supplement on memory in adults

    In their study published in Human Psychopharmacology: Clinical and Experimental, Abbott-Imboden, C., Gonzalez, Y., & Utley, A. (2023) explore the efficacy of a plant-based nootropic supplement and it's effects on memory in adults.

    The study, titled "Efficacy of the nootropic supplement Mind Lab Pro on memory in adults: Double-blind, placebo-controlled study," sets out to assess the impact of this supplement on various aspects of memory, including immediate and delayed recall, among healthy adults.

    Employing a rigorous double-blind, placebo-controlled methodology, this research aims to provide empirical evidence on whether plant-based nootropic blend can significantly enhance memory functions.


    The study by aimed to rigorously evaluate the effectiveness of a plant-based nootropic blend on memory functions in healthy adults.

    This inquiry was structured to:

    1. Assess the impact of the nootropic blend on various dimensions of memory, including auditory, visual, visual working memory, immediate, and delayed recall. The goal was to ascertain whether this dietary supplement could significantly enhance memory performance over a specified period.
    2. Utilize the Wechsler Memory Scale Fourth UK Edition (WSM-IV UK) as a comprehensive tool for measuring these memory functions. By adopting this well-established assessment method, the research intended to provide a nuanced understanding of how the nootropic blend might influence different aspects of memory.


    This exploration was grounded in the broader context of growing interest in dietary supplements, particularly nootropics, aimed at improving cognitive functions among the general population.

    By focusing on a diverse age range of participants, the research sought to contribute meaningful insights into the cognitive benefits of nootropics, thereby addressing a significant gap in the existing literature on dietary supplements and memory enhancement.


    The study recruited 49 healthy individuals through community advertisements. Eligibility criteria included being aged between 20 and 69, ability to understand and sign informed consent, and ability to travel to the university for data collection.

    Participants were excluded if they had any visual or auditory conditions, were taking any medication or supplements, or had any known medical conditions.

    The experimental group consisted of 36 participants, while the control group had 13.

    A double-blind, placebo-controlled, pseudo-randomized design was used. Participants were assigned to either receive the nootropic blend or a matched placebo (microcrystalline cellulose) for 30 days.

    Both the participants and researchers were blinded to the assignments. Participants underwent pre- and post-assessment using the Wechsler Memory Scale Fourth UK Edition (WMS-IV UK).

    The nootropic blend was administered according to the manufacturer's recommendations, with two capsules taken daily, preferably with food.

    The WMS-IV UK, a comprehensive memory assessment tool, was used to evaluate various memory functions, including auditory memory, visual memory, visual working memory, immediate recall, and delayed recall. This battery of tests allowed for a detailed analysis of different forms of memory, crucial for the study's aims.

    The study employed IBM SPSS Statistics V27 for data analysis.

    The Shapiro-Wilk test assessed data normality, and appropriate parametric or non-parametric tests were applied based on the results.

    Analyses included paired samples t-tests or Wilcoxon signed-rank tests for within-group comparisons, and mixed model ANOVAs or Kruskal-Wallis tests for between-group comparisons. A p-value of ≤0.05 was considered statistically significant.


    The results indicated that participants in the experimental group, who received the nootropic blend, exhibited significant improvements in auditory memory.

    This was a notable finding as auditory memory is crucial for the retention and recall of information heard, suggesting that the nootropic blend may facilitate better auditory information processing and storage.

    Visual memory testing also yielded significant positive results for those taking the nootropic blend.

    The ability to remember visually presented information, such as pictures or sequences, was enhanced, suggesting an improvement in the cognitive processing of visual stimuli.

    Visual working memory, which involves the capacity to manipulate visual information in short-term memory, showed improvement in the experimental group.

    This enhancement could indicate a broader application of the nootropic blend in improving the cognitive tasks that require holding and manipulating information in mind, a key component of problem-solving and reasoning.

    Immediate recall abilities were significantly improved in the experimental group as well.

    This aspect of memory is vital for the retention and prompt recall of information without delay, an improvement in which underscores the potential of the nootropic blend in aiding learning and immediate memory tasks.

    The image displays two bar graphs, labelled A and B, showing the results of tests conducted on a control group and an experimental group before and after taking the nootropic blend.

    In graph A, both the control and experimental groups show an increase in their immediate recall scores from the pre-test to the post-test.

    The control group had a median (M) score increase from 48 to 49.5, and the experimental group's median score increased from 37 to 47.5, which is a more substantial improvement.

    Graph B shows the change in scaled scores (R), indicating that the experimental group had a greater increase in scores than the control group.

    Both the control and experimental groups got better at recalling information after taking the nootropic blend, with the experimental group showing a much larger improvement.

    When looking at the change in scores before and after this event, the experimental group had a notably larger increase compared to the control group. The statistics suggest these findings are not due to random chance, meaning there's something about the intervention that genuinely helped improve recall, especially for the experimental group.

    Delayed recall, or the ability to remember information after a period of time, also saw significant improvements among participants taking the nootropic blend.

    This finding suggests that the nootropic blend may not only aid in immediate memory recall but also in the retention of information over longer periods, which is essential for the learning process and the consolidation of long-term memories.


    Graph A indicates the scores for delayed recall before and after the intervention. Both groups seem to have higher scores in the post-test compared to the pre-test, but based on the provided results, only the experimental group showed a statistically significant improvement.

    This is illustrated by the higher post-test bar for the experimental group compared to the pre-test, which is not the case for the control group where the bars are relatively similar in height.

    Graph B shows the change in scaled scores for delayed recall (DR) between the pre- and post-tests for both groups.

    The control group had a slight increase, while the experimental group had a more considerable increase, which was statistically significant (p = 0.034) according to the Kruskal Wallis test.

    This indicates that the experimental group's delayed recall ability improved significantly compared to the control group following the intervention.

    While the control group showed no significant improvement in delayed recall, the experimental group experienced a notable enhancement in their memory abilities after taking the nootropic blend.

    Furthermore, when comparing the two groups, the change in memory performance from before to after the intervention was significantly greater in the experimental group for both immediate and delayed recall.

    This suggests that the nootropic blend had a positive effect on memory functions in the experimental group.

    The administration of the nootropic blend resulted in significant improvements across a variety of memory tests, including auditory memory, visual memory, visual working memory, immediate recall, and delayed recall.

    These results suggest that the nootropic blend has a broad and positive effect on cognitive functions related to memory, potentially offering a valuable cognitive enhancement for adults looking to improve their memory performance.


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    What the Science Says (and Doesn't Say)

    This discussion synthesizes the key findings and inconclusive results from the four distinct studies we've looked at, highlighting the positive impacts on cognitive performance, emotional states, and physical capabilities, as well as the areas where further research is warranted.

    Positive Findings Across Studies

    • Enhanced Cognitive Task Performance: The chronic supplementation study by Wightman et al. demonstrated notable improvements in the speed of cognitive task performance among older adults experiencing subjective memory decline. This was accompanied by changes in urinary dopamine metabolites and gut microbiome profiles, suggesting a biological underpinning for the cognitive benefits observed.
    • Acute Cognitive and Emotional Benefits: Medrano et al.'s investigation into the acute effects of a multi-ingredient nootropic in young adults revealed significant enhancements in processing speed, inhibitory control, working memory, and cognitive flexibility. Importantly, these cognitive improvements were accompanied by increased creativity and positive emotional states, without adverse effects on heart rate or emotional well-being.
    • Stimulant-Free Cognitive and Physical Performance Enhancement: The study conducted by Shields et al. compared a multi-ingredient cognitive formula against caffeine and a placebo, showcasing its ability to improve alertness, focus, motivation, and calmness, in addition to psychomotor performance metrics such as reaction times and vertical jump power. This positions the formula as a promising alternative to caffeine for those seeking both mental and physical performance enhancements without the common side effects of stimulants.
    • Memory Function Improvements: Abbott-Imboden et al.'s research on the efficacy of a plant-based nootropic supplement revealed significant improvements in various memory functions, including auditory and visual memory, immediate and delayed recall. This suggests that certain nootropic blends can effectively enhance memory performance in healthy adults.

    Inconclusive Results and Areas for Further Research

    Despite these positive outcomes, several studies highlighted areas where results were less clear or where further investigation is needed:

    • Impact on Memory and Other Cognitive Domains: While certain cognitive domains like task speed and memory showed improvement, other areas, such as verbal fluency and motivation, did not exhibit significant changes. This inconsistency calls for more targeted research to understand the specific cognitive functions that benefit from nootropic supplementation and the mechanisms behind these effects.
    • Long-Term Effects and Mechanisms: The studies, while indicating acute and chronic benefits of nootropic supplementation, also underscore the necessity for long-term research to fully understand the sustainability of these cognitive improvements and the biological mechanisms involved.
    • Variable Response Across Demographics: The varying responses to nootropic supplementation across different age groups and health statuses suggest that individual differences may play a significant role in the efficacy of these supplements. Future research should consider these variables to tailor nootropic interventions more effectively.
    • Safety and Side Effects: Although the studies reviewed did not report significant adverse effects, the comprehensive assessment of the safety profile of multi-ingredient nootropic stacks remains a critical area for ongoing research.

    The collective evidence from these studies provides a cautiously optimistic view of the potential for multi-ingredient nootropic stacks to enhance various aspects of cognitive function, emotional well-being, and physical performance.

    However, it also highlights the complexity of this field, where individual differences, the specificity of cognitive effects, and the mechanisms of action require further elucidation.

    Important: It's essential to acknowledge that the existing research on nootropics only scratches the surface of the broader scientific exploration into these compounds. Present studies often concentrate on single nootropics or relatively simple combinations of one or two ingredients. We strongly encourage individuals to conduct their own investigations into this field. For those with an interest in particular nootropics, there is a wealth of literature available that assesses the effects of specific nootropics on targeted outcomes. This rich repository of information can serve as a valuable resource for understanding the potential benefits and mechanisms of various nootropic compounds.


    Data versus Anecdotal Evidence

    Navigating the scientific landscape regarding nootropics reveals a spectrum of studies, some of which present seemingly contradictory results.

    This variance is not unique to nootropics but reflects the inherent complexities of scientific research across disciplines. Understanding these discrepancies requires examining the multifaceted nature of both empirical data and anecdotal evidence.

    Scientific Studies: Diverse Outcomes Explained

    • Variability in Study Design: The methodologies employed, such as the size of the participant group, study duration, and cognitive tests used, greatly influence outcomes. Small sample sizes may not provide a comprehensive view, and different tests can yield varied efficacy measures.
    • Diversity in Populations: Participant demographics, including age and health status, significantly affect nootropic effects. What benefits one group may not hold the same value for another, highlighting the importance of considering the target population in evaluating study results.
    • Complexity of Nootropic Stacks: Research often investigates nootropics as part of a stack, adding complexity due to the interactions between components. Variations in formulation and dosage further contribute to diverse study outcomes.
    • Subjective versus Objective Measures: Reliance on subjective cognitive assessments can introduce bias, whereas objective measures might not fully capture individual cognitive enhancements, illustrating the challenge in quantifying cognitive benefits.
    • Biological Individuality: The unique genetic, metabolic, and neurochemical profiles of individuals mean that nootropics may affect people differently, a key factor in the varied results seen in research.
    • Publication Bias: The preference for publishing studies with positive results over those that are negative or inconclusive can distort the perceived effectiveness of nootropics, underscoring the need for a balanced view of the literature.

    The Value of Anecdotal Evidence

    Amidst the scientific inquiry, the experiences of individuals using nootropics enrich our understanding. Online forums, product reviews, and social media offer a plethora of testimonials detailing cognitive and mood improvements attributed to nootropic use.

    These narratives, characterized by their volume and diversity, provide insights that complement scientific findings.

    The real-world application of nootropics, as described by users, fills gaps left by the controlled, sometimes narrow focus of scientific studies.

    Personal stories of enhanced cognitive function, mood, and overall well-being add a valuable dimension to our knowledge, emphasizing the substance's potential impact on daily life.

    Integrating Perspectives for a Fuller Understanding

    Both rigorous scientific research and anecdotal evidence play crucial roles in comprehending the efficacy and safety of nootropics.

    While acknowledging the limitations and strengths of each approach, integrating these perspectives offers a more nuanced understanding of nootropics' potential benefits and challenges.

    This balanced view not only promotes a deeper appreciation of scientific intricacies but also honors the personal experiences of those who have found value in nootropic supplements.

    Together, these facets contribute to a broader dialogue on cognitive enhancement and human potential, steering the conversation toward informed, evidence-based conclusions.


    Silver capsules and blue botanicals on a modern, white, sleek display



    The realm of nootropics symbolizes a deep-seated human desire to reach the zenith of cognitive functioning, reminding us of both the power and intricacy of the human brain.

    Research from figures such as Wightman, Medrano, Shields, and Abbott-Imboden sheds light on the positive effects that multi-ingredient nootropic stacks can have on cognitive performance, memory, emotional well-being, and physical abilities.

    However, it also brings to the forefront the need for more detailed studies to understand the underlying mechanisms, the long-term impact, and how individual differences affect the efficacy of these supplements.

    The insights we currently hold are invaluable, yet they also highlight the necessity for careful consideration and personal due diligence.

    For those drawn to the potential of nootropic stacks, embarking on this journey requires a mindful approach—balancing scientific findings, personal cognitive objectives, and the wisdom gained from cautious experimentation.

    The pursuit of cognitive enhancement through supplements should be complemented with a well-rounded approach to health and well-being.

    This includes proper nutrition, regular physical activity, adequate sleep, stress management, and engaging in mental exercises.

    A holistic lifestyle serves as the foundation upon which nootropic benefits can be maximized, ensuring that the journey towards cognitive enhancement is both effective and sustainable.

    Recognizing the importance of this comprehensive approach can empower individuals to not only achieve optimal cognitive function but also maintain overall health and well-being.

    For those interested in beginning their journey with nootropics, our Mood & Wellbeing Nootropic Supplement at nooroots provides a carefully curated introduction to this exciting world of cognitive enhancement.


    Explore the top natural nootropics tailored to your specific needs and learn about the science behind common health problems 

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